In the absence of maternal stimuli, children exhibited immature amygdala-prefrontal connectivity. Children, but not adolescents, showed evidence of maternal buffering, such that maternal stimuli suppressed amygdala reactivity. This investigation examined a potential mechanism through which caregivers provide regulatory influences in childhood. In (semi-)altricial species, caregivers provide potent affect regulation when mature neurocircuitry is absent. Mature amygdala-prefrontal circuitry regulates affect in adulthood, but shows protracted development.
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